Taisuke Tomita: Novel Aβ degrading enzyme and astrocytes. The 26th Adler Symposium will focus on four major themes: potential role of lifestyle in neurodegeneration. Feburary 6-8, 2018, San Diego, USA
Kiwami Kidana, Takuya Tatebe, Kaori Ito, Norikazu Hara, Akiyoshi Kakita, Takashi Saito, Yasuyoshi Ouchi, Takeshi Ikeuchi, Mitsuhiro Makino, Takaomi C. Saido, Masahiro Akishita, Takeshi Iwatsubo, Yukiko Hori, Taisuke Tomita: Loss of astrocyte-derived kallikrein 7 exacerbates amyloid pathology and neuritic change in Alzheimer disease. AD/PD2017, March 29-April 2, 2017. Vienna, Austria
Shuta Ozawa, Atsuhiko Taniguchi, Ryuto Kino, Takashi Saito, Takaomi C. Saido, Youhei Sohma, Yukiko Hori, Motomu Kanai and Taisuke Tomita: Biochemical analysis of oxygenated Aβ by in vivo photooxygenation system. 2017年3月24-27日 日本薬学会第137年会 仙台
Taisuke Tomita: Pathological impact of astrocyte-mediated proteolytic processing on amyloid-s deposition. Neuroscience 2016, November 13, San Diego, USA
Nobuyuki Kimura, Noya Ueda, Taisuke Tomita, Katsuhiko Yanagisawa: Retromer and Rab2-dependent trafficking are involved in PS1 degradation by proteasomes in endocytic disturbance. Neuroscience 2016, November 14, San Diego, USA
Ihori Ebinuma, Yukiko Hori, Taisuke Tomita: Genome wide screening of molecules involved in Aβ uptake by CRIPSR/Cas9 system. Neuroscience 2016, November 16, San Diego, USA
Taisuke Tomita: Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease. October 3, 2016. 56th Advances in Biological Regulation. Bologna, Italy
Taisuke Tomita, Kiwami Kidana, Takuya Tatebe, Kazunori Kikuchi, Takeshi Ikeuchi, Takaomi Saido, Masahiro Akishita, Takeshi Iwatsubo and Yukiko Hori: Identification of kallikrein-related peptidase 7 as a novel amyloid-β peptide-degrading protease secreted from astrocyte. IUBMB symposium (XVth International symposium) on Proteases, Inhibitors and Biological Control. September 17-21, 2016. Portoroz, Slovenia
Kaori Ito, Takuya tatebe, Kunimichi Suzuki, Taisuke Tomita, Mitsuhiro Makino: The Inhibitory effect of memantine on the production of Aβ peptides. AAIC2016, July 24-28, 2016. Toronto, Canada
Kunihiko Kanatsu, Yukiko Hori, Sho Takatori, Taisuke Tomita: Partial loss of Picalm predominantly affects the amyloid-β deposition in the piriform cortex of mouse model of Alzheimer disease. AAIC2016, July 24-28, 2016. Toronto, Canada
Taisuke Tomita: Effect of γ-secretase inhibitor and modulator on the conformation of presenilin 1 May 9-11, 2016. 4th International Conference on Molecular Neurodegeneration (ICMN2016). Seoul, Korea
Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita: Identification of genetic regulators for Aβ production by CRISPR/Cas9 based screening. 2016年11月26日 第38回神経組織培養研究会 横浜
Sho Takatori, Shingo Kimura, Takashi Saito, Takaomi C. Saido, Junko Sasaki, Takehiko Sasaki, Taisuke Tomita: Analysis of the pathological role of an Alzheimer’s disease genetic risk factor, INPP5D/SHIP1. 2016年9月26日 第88回日本生化学会大会 仙台
Takuya Tatebe, Kiwami Kidana, Yukiko Hori, Taisuke Tomita: Identification of KLK7 as a novel amyloid-β peptide-degrading prteiase secreted from astrocytes. 2016年9月26日 第88回日本生化学会大会 仙台
Misaki Kimura, Takafumi Yumoto, Yosuke Nao, Taisuke Tomita: Effects of missense mutations associated with autism spectrum disorder on the processing and function of synaptic adhesion molecule Neuroligin 4X. 2016年7月20日 第39回日本神経科学大会 横浜
Shingo Kimura, Sho Takatori, Yukiko Hori, Taisuke Tomita: Analysis of functional significance of phosphoinositide phosphatase INPP5D in the pathogenesis of Alzheimer disease. 2016年4月23日 第16回東京大学生命科学シンポジウムBIO UT 東京
Misaki Kimura, Takafumi Yumoto, Ryota Nagatomo, Yosuke Nao, Taisuke Tomita: Effects of missense mutations associated with autism spectrum disorder on the processing and function of synaptic adhesion molecule Neuroligin 4X. 2016年4月23日 第16回東京大学生命科学シンポジウムBIO UT 東京
田村謙典、堀由起子、富田泰輔：EphA4を介したアルツハイマー病原因物質Aβ産生量制御機構の解明 2016年4月23日 第16回東京大学生命科学シンポジウムBIO UT 東京
Kazunori Kikuchi, Kiwami Kidana, Takuya Tatebe, Yukiko Hori, Taisuke Tomita: Kallikrein-related peptidase 7 is a novel amyloid-β peptide-degrading protease secreted from astrocytes. 2016年4月23日 第16回東京大学生命科学シンポジウムBIO UT 東京＜優秀ポスター賞＞
Taisuke Tomita: Astrocyte-mediated proteolytic mechanism regulates amyloid-β metabolism in brain. November 23, 2015. Cambridge - U Tokyo workshop. Cambridge, UK
Taisuke Tomita: Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease. October 8, 2015. 9th General Meeting of the International Proteolysis Society. Penang, Malaysia
Kunihiko Kanatsu, Yukiko Hori, Toshio Watanabe, Takeshi Iwatsubo, Taisuke Tomita: Partial loss of CALM function impacts on the γ-secretase-mediated Aβ42 production and amyloid deposition in vivo. 9th General Meeting of the International Proteolysis Society. October 6, 2015. Penang, Malaysia
Takuya Tatebe, Kiwami Kidana, Yukiko Hori, Masahiro Akishita, Yasuyoshi Ouchi, Takeshi Iwatsubo, Taisuke Tomita: IDENTIFICATION OF KLK7 AS A NOVEL AMYLOID-β PEPTIDE-DEGRADING PROTEASE SECRETED FROM ASTROCYTES. The 6th annual International Symposium on Kallikreins and Kallikrein-Related Peptidases. October 1, 2015. Brisbane, Australia. < Best Poster ECR Presentation>
Taisuke Tomita, Kiwami Kidana, Takuya Tatebe, Yasuyoshi Ouchi, Masahiro Akishita and Takeshi Iwatsubo: Pathophysiological Impact of Astrocyte-Derived Kallikrein-Related Peptidase 7 on Aβ Metabolism in Brain. AAIC2015, July 18-25, 2015, Washington DC, USA
Taisuke Tomita, Toji Miyagawa, Kunihiko Kanatsu, Ihori Ebinuma, Ryota Ojima, Yuichi Morohashi, Shoji Tsuji, Yukiko Hori, Takeshi Iwatsubo: Membrane trafficking of β- and γ-secretases regulated by genetic risk factor proteins for Alzeimer disease impacts on the production of amyloid-β proteins. AD/PD 2015, March 18-22, 2015, Nice, France
Taisuke Tomita: Pathophysiological functions of genetic modifiers of Alzheimer disease. March 12, 2015. International Symposium "Asian Aging Core for Longevity (AACL) 2006-2015, 10 years and Beyond", Osaka
Kunihiko Kanatsu, Yukiko Hori, Toshio Watanabe, Takeshi Iwatsubo, Taisuke Tomita: Partial loss of CALM function impacts on the γ-secretase-mediated Aβ42 production and amyloid deposition in vivo. 2015年6月27日 第15回東京大学生命科学シンポジウムBIO UT 東京＜優秀ポスター賞＞
Takuya Tatebe, Kiwami Kidana, Yukiko Hori, Yasuyoshi Ouchi, Masahiro Akishita, Takeshi Iwatsubo, Taisuke Tomita: Identification of kallikrein-related peptidase 7 as a novel amyloid-β peptide-degrading protease secreted from astrocytes. 2015年6月27日 第15回東京大学生命科学シンポジウムBIO UT 東京
Yosuke Nao, Taisuke Tomita: Proteolytic Cleavage of Inhibitory Synapse Specific Adhesion Molecule Neuroligin-2. 2015年6月27日 第15回東京大学生命科学シンポジウムBIO UT 東京
Taisuke Tomita, Toji Miyagawa, Tomoki Sasaki, Masaya Fukushima, Ihori Ebinuma, Ryota Ojima, Yuichi Morohashi, Shoji Tsuji, Takeshi Iwatsubo: Endosomal trafficking of BACE1 regulated by BAR domain proteins impacts on the production of amyloid-β proteins. Neuroscience 2014, November 19, Washington DC, USA
Takuya Tatebe, Kiwami Kidana, Masahiro Akishita, Yasuyoshi Ouchi, Takeshi Iwatsubo, Taisuke Tomita: Functional analysis of Aβ-degrading serine protease activity in the supernatant from astrocytic cells. Neuroscience 2014, November 19, Washington DC, USA
Taisuke Tomita, Takafumi Yumoto, Yosuke Nao: Activity-dependent proteolytic processing of synaptic adhesion molecules. “Proteases at work: cues for understanding neural development and degeneration” WORKSHOPS CURRENT TRENDS IN BIOMEDICINE at Campus Antonio Machado. Oct 22-24, 2014, Baeza, Spain
Yosuke Nao, Azusa Shiohara, Takafumi Yumoto, Takeshi Iwatsubo, Taisuke Tomita: Proteolytic cleavage of inhibitory synapse specific adhesion molecule neuroligin-2. “Proteases at work: cues for understanding neural development and degeneration” WORKSHOPS CURRENT TRENDS IN BIOMEDICINE at Campus Antonio Machado. Oct 22-24, 2014, Baeza, Spain
Taisuke Tomita: Mechanistic insight into the gamma-secretase-mediated intramembrane cleavage. Gordon Research Conference on Proteolytic Enzymes & Their Inhibitors. June 22-27, 2014, Lucca, Italy
Taisuke Tomita, Aya Tominaga, Shizuka Takagi-Niidome, Takeshi Iwatsubo: Conformational changes in the transmembrane domains 4 and 5 of Presenilin 1 associated with altered Abeta42 production. AAIC 2014, July 12-17, 2014, Copenhagen, Denmark
Taisuke Tomita: Activity-dependent proteolytic processing and neurodegenerative diseases. 2014年5月10日 マックスプランク協会合同シンポジウム Max Planck Florida Institute for Neuroscience. Jupiter, USA
Kunihiko Kanatsu, Taisuke Tomita: CALM impacts on Aβ42 production ratio through modulation of clathrin-mediated endocytosis of γ-secretase. Gordon Research Conference on Regulated Proteolysis of Cell Surface Proteins. March 30-April 4, 2014, Los Angels, USA
Taisuke Tomita: Structure and function relationships of the gamma-secretase mediated intramembrane cleavage. Gordon Research Conference on Regulated Proteolysis of Cell Surface Proteins. March 30-April 4, 2014, Los Angels, USA
Taisuke Tomita: Physiological and pathological roles of proteolytic processing of autism-related neuroligin proteins. March 16th, 2014. New Frontier of Molecular Neuropathology 2014. Tokyo