Lecture
Lecture print
FY2024 (R6) Morphology (1011126, 2nd grade A1 term)
Date：Thursday, 3rd period, 13:00-14:45
Place：Auditorium
Resume and report assignments will be distributed at ITC-LMS.
FY2024 (R6) Pathology（1011159、2nd grade A2 term）
Date：Thursday, 3rd period, 13:00-14:45
Place：Auditorium
Organizer：Taisuke Tomita（taisuke{at}mol.f.u-tokyo.ac.jp）
Resume will be available on ITC-LMS.
Two report assignments: one required and one elective
Compulsory Assignment
1. Summarize the pathology, clinical manifestations, pathophysiology, epidemiology, and recent research results on etiology of the disease(s) of interest to you, including those not covered in the lecture, and do not include treatment methods.
Other report assignments will be distributed at ITC-LMS on the last day of the lecture.
Due：Mid-February
Submission address：ITC-LMS
Seminar
June 14, 2024
Tau biomarkers and kinetics in Alzheimer’s disease and tauopathies
Chihiro Sato, Ph.D.
Assistant Professor of Neurology
Assistant Director of the Tracy Family SILQ Center
Washington University School of Medicine
Date：Friday, June 14, 2024, 3:00pm-4:00pm
Place：Auditorium, School of Pharmaceutical Sciences, The University of Tokyo
Dr. Sato conducts research on tau metabolism and biomarkers at Washington University School of Medicine in St. Louis, USA. In this seminar, we will have an opportunity to hear about his research results related to changes in tau protein metabolism in Alzheimer's disease and primary tauopathies. We are looking forward to welcoming not only graduate students but also PIs and young researchers. We also request that those who are interested in studying abroad attend this meeting to interact with students and young researchers who are thinking about studying abroad. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel: 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
December 4, 2023
Molecular Pathogenesis of Alzheimer’s Disease: Role of the Gut Microbiome
Sangram S. Sisodia, Ph.D.
Thomas Reynolds Sr. Family Professor of Neurosciences Professor
Director, Center for Molecular Neurobiology
Departments of Neurobiology and Neurology
The University of Chicago
Date：Friday, December 4, 2023, 11:00 a.m.-12:00 p.m.
Place：West Lecture Room, West Bldg. 1F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Sisodia has been working on metabolic analysis of amyloid-β precursor protein (Sisodia et al., Science 1990), functional analysis of presenilin, the gene responsible for familial Alzheimer's disease (Thinakaran et al., Neuron 1996), and the development of mouse models of amyloid plaque accumulation based on familial genetic mutations. In addition, he has been conducting pioneering research on the molecular pathogenesis of Alzheimer's disease, including the establishment of mouse models of amyloid plaque accumulation based on familial genetic mutations (Borchelt et al., 1997), and the effects of environmental factors on neural stem cells and amyloid plaque accumulation (Lazarov et al., Cell 2005). He is a world-renowned researcher who has consistently pioneered research on the molecular pathogenesis of Alzheimer's disease. In connection with our strategic partnership with the University of Chicago, we have arranged for him to come to Japan to discuss his recent research results on the microbiome and Alzheimer's disease pathology. We look forward to welcoming not only graduate students but also PIs and young researchers. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
September 8, 2023
How tau becomes toxic: the good, the bad, and the ugly
Li Gan, Ph.D.
Director of the Helen and Robert Appel Alzheimer’s Disease Research Institute
Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases
Weill Cornell Medicine
Date：Friday, September 8, 2023, 2:00pm-3:00pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Gan studies innate immunity and proteostasis in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). He has reported the relationship between abnormal endolysosomal function and the Aβ degradation system in AD, and abnormal acetylation and tau degradation and toxicity in FTD. He is also a world-renowned researcher on the pathological functions of microglia in aging and disease, including recent studies on how abnormalities in the innate immune system, such as TREM2 and cGAS-STING pathways, lead to the progression of neurodegenerative diseases. We have arranged an opportunity to hear about his latest research findings during his visit to Japan. We look forward to welcoming a large number of PIs and young researchers as well as graduate students. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
2023年7月28日
Understanding the synapse organisation from structure to behaviour
Kunimichi Suzuki, Ph.D.
Investigator Scientist
Dr. Radu Aricescu Laboratory
MRC Laboratory of Molecular Biology
Date：Friday, July 28, 2023, 1:00pm-2:00pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Suzuki received his PhD degree from the Graduate School of Pharmaceutical Sciences, the University of Tokyo, where he studied activity-dependent proteolysis and synaptic plasticity of the synaptic adhesion molecule neuroligin 1. He then worked as a postdoctoral fellow in the Department of Physiology at Keio University School of Medicine, where he analyzed microglial dynamics by in vivo two-photon imaging and developed artificial synaptic guidance molecules (synaptic organizers) to restore injured neuronal circuits. Currently at the MRC LMB, he is an up-and-coming researcher who studies the interactions between neurons, glial cells, and extracellular matrix in terms of molecular structure and function to elucidate new mechanisms and link them to drug discovery. We have arranged an opportunity to hear about his latest research results during his visit to Japan. We look forward to welcoming not only graduate students but also many PIs and young researchers. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
March 14, 2023
APOE and ABCA7 in lipid metabolism and Alzheimer's disease
Takahisa Kanekiyo, M.D., Ph.D.
Associate Professor of Neurology
Mayo Clinic Jacksonville
The University of Chicago
Date：Tuesday, March 14, 2023, 4:30pm-5:30pm
Place：Auditorium, Faculty of Pharmaceutical Sciences Building, The University of Tokyo
Dr. Takahisa Kanekiyo of Mayo Clinic Jacksonville has made great achievements in his research on the physiological and pathological functions of APOE, a genetic risk factor for the development of Alzheimer's disease, and its related proteins LRP1 and ABCA7. Recently, he has been conducting pioneering research using iPS cells and is a world leader in basic research on Alzheimer's disease. We look forward to seeing you at the conference. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
February 15, 2023
Molecular Pathogenesis of Alzheimer’s Disease: Role of the Gut Microbiome
Sangram S. Sisodia, Ph.D.
Thomas Reynolds Sr. Family Professor of Neurosciences
Director, Center for Molecular Neurobiology
Professor, Departments of Neurobiology and Neurology
The University of Chicago
Date：Wednesday, February 15, 2023, 4:00pm-5:00pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
With the support of the Strategic Partnership University Project, we are pleased to host a seminar with Dr. Sisodia, a world-renowned researcher who has consistently pioneered research on the molecular pathogenesis of Alzheimer's disease. During his visit to Japan, Dr. Sisodia will share his recent research results on the microbiome and Alzheimer's disease pathophysiology. For details, please click here. We are looking forward to seeing not only graduate students but also PIs and young researchers.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
December 8, 2020
Maladaptive microglial response in tauopathy
Li Gan, Ph.D.
Director, Helen and Robert Appel Alzheimer’s Disease Research Institute
at Weill Cornell Medicine
Professor, Burton P. and Judith B. Resnick Distinguished in Neurodegenerative Diseases
Date：Monday, December 8, 2020, 9:00 a.m. - 10:30 a.m.
Place：Online
Dr. Li Gan is at the forefront of research on the pathological function of microglia in Alzheimer's disease and frontotemporal lobar degeneration. We have asked him to give an online lecture as the 3rd International Distinguished Lecture in Life Science and Technology. The lecture is open to everyone, both on- and off-campus. Please click here for registration information (UTokyo account verification is required for on-campus participants). We look forward to seeing you there.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
November 18, 2020
Workshop on the future of therapeutic development against neurodegenerative diseases
Date：Wednesday, November 18, 2020, 5:00 PM - 8:00 PM
Place：Zoom
With the support of the Strategic Partnership University Project, we will host an online international workshop with the University of Cambridge. Six leading researchers will present the latest findings on the pathogenesis of neurodegenerative diseases and the potential for developing new therapies.
Speakers
Dr. Peter St. George-Hyslop (CIMR)
“Physiological and pathological protein phase separation in neurons”
Dr. Tadafumi Hashimoto (UT)
“Neurotoxicty and interneuronal transmission of FUS protein”
Dr. Michel Goedert (LMB)
“Cryo-EM structures of amyloid filaments from human brain”
Dr. Airi Tarutani (UT)
“Template-dependent amplification of tau aggregates in cultured cells”
Dr. Kunimichi Suzuki (LMB)
“Building a new bridge a cross the synaptic cleft”
Dr. Yukiko Hori (UT)
“Development of photooxygenation technology towards therapeutic strategy against Alzheimer disease”
For details, please click here. Registration is now closed, but please contact Prof. Tomita directly if necessary.
We look forward to seeing you there.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
January 30, 2020
International symposium for Bilateral Joint Research Project between Lithuania and Japan
Date：Thursday, January 30, 2020, 1:00 p.m. - 5:00 p.m.
Place：Graduate School Lecture Room, Faculty of Pharmaceutical Sciences, The University of Tokyo
We are pleased to invite Dr. Vilmante Borutaite and Dr. Ramune Morkuniene to an international symposium in relation to the bilateral joint research project between Lithuania and Japan. The symposium will be held at the University of Tokyo.
Keynote lecture
Dr. Takeshi Iwatsubo
"Very early treatment of Alzheimer's disease--to stop before symptoms begin"
Speakers
Dr. Sho Takatori
Dr. Taisuke Tomita
Dr. Vilmante Borutaite
Dr. Ramune Morkuniene
For details, please click here. We look forward to seeing you there.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
November 18, 2019
Development, Improvement and Application of FRET Biosensors
Masato Maesako, Ph.D.Instructor
Department of Neurology, Alzheimer's Disease Research Unit
Massachusetts General Hospital & Harvard Medical School
Date：Monday, November 18, 2019, 4:30pm-5:30pm
Place：Seminar Room 1, 2F, Education and Research Building, School of Medicine, The University of Tokyo
Green fluorescent protein (GFP) has been applied to the development of biosensors that enable visualization of molecular activities and cellular functions in living cells. Dr. Masato Maesako is interested in the molecular activity and structural changes associated with Alzheimer's disease using the molecular imaging technique called FRET (Fluorescence Resonance Energy Transfer). We have arranged an opportunity to hear about his latest results on the occasion of his return to Japan. We look forward to seeing you there. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
November 11, 2019
Biochemical signal transduction in single dendritic spines
Ryohei Yasuda, Ph.D.Director
Max Planck Florida Institute for Neuroscience
Date：Monday, November 11, 2019, 3:00pm-4:00pm
Place：Auditorium, Faculty of Pharmaceutical Sciences, The University of Tokyo
After receiving his Ph.D. in 1998, Dr. Ryohei Yasuda became a postdoctoral fellow in Svoboda's lab at Cold Spring Harbor Laboratory, an Assistant Professor at Duke University in 2005, and a Scientific Director at Max Planck Florida Institute for Neuroscience in 2012. In 2012, he became an Assistant Professor at Duke University, and in 2012, he became the Scientific Director of the Max Planck Florida Institute. Dr. Yasuda is one of the world's pioneers in the development of imaging and molecular manipulation techniques using two-photon excitation. We have arranged an opportunity to hear about his latest achievements on the occasion of his return to Japan. We look forward to seeing you there. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
March 15, 2019
Charting the Origins of Behavioral Deficits in Autism Matthew P. Anderson, M.D., Ph.D.
Associate Professor, Harvard Medical School
Faculty, Program in Neuroscience, Harvard Medical School
Investigator, Children's Hospital Intellectual and Developmental Disabilities Research Center (IDDRC)
Director of Neuropathology, Beth Israel Deaconess Medical Center
Consultant in Neuropathology, Boston Children's Hospital
Neuropathologist and Investigator, The Center For SUDEP Research Morphometric Core
Director (Boston Node) and Clinical Neuropathologist, Autism BrainNET
Departments of Neurobiology and Neurology Director
Date：Friday, March 15, 2019, 10:00 a.m. - 11:00 a.m.
Place：Seminar Room 6, 13th Floor, Education and Research Building, Faculty of Medicine, The University of Tokyo
Dr. Anderson is a world-renowned researcher in the generation of mouse models of psychiatric disorders such as autism and epilepsy and their molecular and cellular pathogenesis (Zhou et al. Nature Medicine (2009); Smith et al. Nature (2017)). On the occasion of his visit to Japan, we had the opportunity to ask him about his latest research results. We look forward to welcoming not only graduate students but also PIs and young researchers.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
December 7, 2018
Role of the Gut Microbiome on Amyloidogenesis and Microglial Phenotypes in Transgenic Mouse Models
Sangram S. Sisodia, Ph.D.
Thomas Reynolds Sr. Family Professor of Neurosciences Professor
Departments of Neurobiology and Neurology Director
The University of Chicago
Date：Friday, December 7, 2018, 5:00 p.m. - 6:00 p.m.
Place：Seminar Room 6, 13th Floor, Education and Research Building, School of Medicine, The University of Tokyo
Dr. Sisodia has been working on metabolic analysis of amyloid-β precursor protein (Sisodia et al., Science 1990), functional analysis of presenilin, the gene responsible for familial Alzheimer's disease (Thinakaran et al., Neuron 1996), and the effects of familial genetic variation and environmental factors on He is a world-renowned researcher in molecular and cellular pathology research related to Alzheimer's disease, including the elucidation of the effects of familial genetic mutations and environmental factors on amyloid plaque accumulation (Borchelt et al., Neuron 1997; Lazarov et al., Cell 2005; Choi et al., Neuron 2008). We had the opportunity to hear about his latest research findings on the impact of the microbiome (gut microbiota) on microglial changes in the central nervous system and the pathophysiology of amyloid accumulation. We look forward to welcoming not only graduate students but also PIs and young researchers. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
October 26, 2018
Regulation of Endosomal Trafficking by Cdk5 - Brain Development and Disease
Shinichi Hisanaga
Professor Emeritus
Graduate School of Science and Engineering, Tokyo Metropolitan University
Date：Friday, October 26, 2018, 4:50 p.m. - 6:35 p.m.
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Shinichi Hisanaga is a leading researcher of Cdk5 in Japan who has long been analyzing the function of cyclin-dependent kinase 5 (Cdk5), which is specifically expressed in neurons. Cdk5 is a unique enzyme that is involved in various aspects of neural activity in the brain. In this lecture, he will discuss the novel function of Cdk5 in membrane trafficking and its relation to Alzheimer's disease, which he has recently revealed. We look forward to seeing you there. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita、Airi Tarutani
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
October 19, 2018
Learning from the Mechanism of Parkinson's Disease Pathogenesis Ubiquitin, Mitochondria, and Mitophagy
Noriyuki Matsuda
Project Leader, Ubiquitin Project
Tokyo Metropolitan Institute of Medical Science
Date：Friday, October 19, 2018, 4:50pm-6:35pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Noriyuki Matsuda is a world-leading researcher in the biochemical analysis of Parkin and PINK1, the genes responsible for juvenile Parkinson's disease. In particular, he has conducted pioneering research related to mitochondrial quality control, demonstrating that PINK1 phosphorylates Parkin and ubiquitin during mitochondrial loss of membrane potential, which activates Parkin, a ubiquitin ligase. Not only graduate students but also PIs and young researchers are welcome to attend. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita、伊藤弦太
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
September 10, 2018
Making the Final Cut:
Pathogenic Amyloid-β Peptide Generation by γ-Secretase Harald Steiner, PhD
Professor, Ludwig-Maximilians University Munich
Date：Monday, September 10, 2018, 2:00pm-3:00pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Steiner is a leading researcher in the biochemical analysis of γ-secretase, the enzyme responsible for the production of amyloid-β, the causative molecule of Alzheimer's disease. In particular, he has been working on a detailed analysis of the mechanism by which γ-secretase hydrolyzes in lipid bilayers, using nonnatural amino acids and chemical biology. We have asked him to give a lecture at our university on the occasion of his visit to Japan for WFSBP2018. We look forward to seeing you there. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
June 22, 2018
Drug Development for Neurologic Diseases:
The examples of Spinal Muscular Atrophy and Alzheimer’s Disease
Alfred Sandrock, MD, PhD
Executive Vice President and Chief Medical Officer
Biogen, Inc.
Date：Friday, June 22, 2018, 1:00pm-2:00pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Sandrock (Biogen), who is developing Nusinersen, the world's first nucleic acid drug approved for SMA as a treatment for neurological diseases, and Aducanumab, an antibody drug candidate for Alzheimer's disease, has been invited to give a seminar. We look forward to seeing you there. This seminar was held as a part of the graduate course “Advanced Basic Pharmaceutical Science IV,” and was followed by a lecture by Visiting Professor Shinichi Torii on “Frontiers of Antibody and Nucleic Acid Drug Development” in the afternoon. This seminar is a part of the Graduate School Lecture “Advanced Basic Pharmaceutical Science IV” and will be followed by “Frontiers of Antibody and Nucleic Acid Drug Development” (2-3 p.m.). For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
October 2, 2017
-FLY me to amazing drugs!-
Masahiro Sonoshita, Ph.D
Postdoctoral Fellow
Departments of Cell, Developmental and Regenerative Biology
Icahn School of Medicine at Mount Sinai (New York, USA)
Departments of Neurobiology and Neurology Director
Date：Monday, October 2, 2017, 2:00pm-3:00pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Many people have long wished to create and use anti-cancer drugs with high efficacy and low side effects. However, the actual drug discovery process is not without its difficulties. There are many challenges, including the need for a great deal of labor, time, and money, and there is no clear methodology for creating a good anti-cancer drug in the first place. Dr. Masahiro Sonoshita is working on the development of a novel, highly efficient and rapid drug discovery platform to solve this problem. In this seminar, we had an opportunity to hear about this approach, which combines Drosophila genetics, drug discovery chemistry, and computational science. We hope to discuss the significance and potential applications of this approach in the field of drug discovery. We look forward to welcoming not only graduate students but also PIs and young researchers. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
September 28, 2017
Modulation of Aβ Deposition by the Microbiome in Mouse Models of AD
Sangram S. Sisodia, Ph.D
Thomas Reynolds Sr. Family Professor of Neurosciences Professor
Departments of Neurobiology and Neurology Director
Center for Molecular Neurobiology
The University of Chicago
Date：Thursday, September 28, 2017, 4:30pm-5:30pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Sisodia started with metabolic analysis of amyloid-β precursor protein (Sisodia et al., Science 1990), followed by functional analysis of presenilin, the gene responsible for familial Alzheimer's disease (Thinakaran et al., Neuron 1996), and the development of (Thinakaran et al., Neuron 1996), the establishment of mouse models of amyloid plaque accumulation based on familial genetic mutations (Borchelt et al., 1997), and the effects of environmental factors on neural stem cells and amyloid plaque accumulation (Lazarov et al., Cell 2005; Choi et al. et al., PNAS 2013). He is a world-renowned researcher who has been consistently conducting pioneering research on the molecular pathogenesis of Alzheimer's disease. During his visit to Japan, we had the opportunity to hear about his recent research results (Minter et al., Sci Rep 2016) on the microbiome and the pathophysiology of Alzheimer's disease. We are looking forward to seeing not only graduate students but also PIs and young researchers. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
July 27, 2017
Identification of a Novel Auxiliary Subunit Regulating GABAA Receptor Complex Formation and Inhibitory Synaptic Transmission
Yamasaki Tokiwa Ph.D
Cellular and Molecular Physiology, Yale University School of Medicine
Susumu Tomita Laboratory
Postdoctoral Associate
Date：Thursday, July 27, 2017, 2:00pm-3:00pm
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Yamazaki is a postdoctoral fellow of Prof. Susumu Tomita, a world-leading researcher in the field of synaptic transmission at Yale University in the United States, and his research aims to elucidate the molecular mechanisms that regulate inhibitory synaptic transmission. In a recent study, Dr. Yamazaki discovered that GABAA receptors, which are responsible for inhibitory synaptic transmission, form a large protein complex in the brain, and identified a novel GABAA receptor binding factor that is essential for their formation. Furthermore, we identified a novel GABAA receptor-binding factor that is essential for the formation of GABAA receptors. We are pleased to have this opportunity to introduce the unique biochemical approach that led to the identification of GARLH and the newly revealed molecular mechanisms that regulate synaptic transmission. We look forward to seeing you there. This seminar is co-sponsored by the Department of Physiological Chemistry. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
October 7, 2016
Molecular Imaging Links Basic and Clinical Dementia Drug Discovery
Makoto Higuchi MD, Ph.D
National Institute of Quantum Science and Technology
Molecular Neuroimaging Research Program
Team Leader, Brain Molecular Dynamics Team
Date：October 7, 2016, 4:50 p.m. - 6:35 p.m.
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Higuchi is a world leader in pathological imaging research of Alzheimer's disease. Dr. Higuchi's development of imaging probes that can be applied to both animal models of disease and humans, and the results of molecular imaging using these probes, have attracted wide attention not only in basic research aimed at elucidating the mechanisms of pathogenesis, but also in clinical research for diagnosis and treatment. Recently, he was awarded the Tsukahara Nakaaki Memorial Prize for the world's first imaging of tau protein, which abnormally accumulates in the brain of patients with Alzheimer's disease. In his graduate course “Advanced Medicinal Pharmacology,” he will explain his remarkable research achievements in an easy-to-understand manner and introduce his latest research activities. We look forward to welcoming not only graduate students but also PIs and young researchers. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita、Yukiko Hori
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
September 30, 2016
Electron microscopic visualization: from whole cells to individual molecules
John E. Heuser, M.D.
Principal Group Leader and Director of the Electron Microscopy Core (京都大学iCeMS)
Emeritus Professor of Biophysics
(Department of Cell Biology and Physiology, Washington University School of Medicine)
Date：Friday, September 30, 2016, 4:50 p.m. - 6:35 p.m.
Place：Graduate School Lecture Room, South Bldg. 4F, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Heuser was the first in the world in the 1970s to successfully capture the structure of neurons at the moment of their aperture release using electron microscopy. Currently, he is a leader of the iCeMS group at Kyoto University and is very busy with his research, traveling back and forth between Japan and the United States. This time, we took advantage of the opportunity of his graduate school lecture “Advanced Medicinal Pharmacology” to have him introduce his latest research. We look forward to welcoming not only graduate students but also PIs and young researchers. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita、Sho Takatori
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
March 9, 2016
Molecular Interaction Analysis Using
a Next-Generation Fermentation Reporter
Dr. Tadafumi Hashimoto
Oligomerization assay of Alzheimer's disease amyloid-β peptide using Split-liciferase
Mitsunori Ota（Promega Corporation）
Intracellular protein-molecule interaction monitoring using NanoBiT novel bimolecular complementation system
Date：Wednesday, March 9, 2016, 11:00 a.m.-12:00 p.m.
Place：Auditorium, Faculty of Pharmaceutical Sciences, The University of Tokyo
Protein-protein interactions (PPIs) are an essential component of intracellular signaling networks, and while there are many ways to monitor PPIs in vitro, there are not many ways to detect them in cells. Promega has developed NanoLucR Binary Technology (NanoBiT), a NanoLucR luciferase-based bimolecular system that enables intracellular PPI detection with two subunit systems: Large BiT (LgBiT ) and Small BiT (SmBiT; 11 amino acid peptide) subunits are expressed as fusions with their respective target proteins, and when PPI occurs, the complementarity of the subunits is promoted, producing a bright light as a luminescent enzyme. In contrast to many split systems, the LgBiT:SmBiT interaction is reversible and rapid dissociation between proteins can be detected. In this seminar, Dr. Tadashi Hashimoto, who has been conducting experiments using Split-luciferase for some time, will give a presentation. After the lecture, we will introduce the features of NanoBiT technology, its application to PPI analysis, and the difference between NanoBiT and NanoBERT.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
September 30, 2015
An rAAV Toolkit to Accelerate Preclinical Therapeutic Discovery for Neurodegenerative Diseases
Todd E. Golde, M.D., Ph.D.
Director, Center for Translational Research in Neurodegenerative Disease (CTRND)
Professor, Neuroscience
Investigator, McKnight Brain Institute and CTRND at University of Florida
Date：Wednesday, September 30, 2015, 1:30pm-2:30pm
Place：Graduate School Lecture Room, South Building, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Golde was the first in the world to report the molecular and cellular biology of amyloid-β protein (Neuron 1990, Science 1992), and has been actively engaged in research ever since. At the same time, he is the director of CTRND at the University of Florida, where he oversees research on a variety of neurodegenerative diseases. We have arranged for him to come to Japan this time to talk about his latest achievements. We look forward to seeing you there. We look forward to seeing you there. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
May 29, 2015
NOTCH proteolysis and targeting in cancer and normal tissues models
Dr. Marc Vooijs
Professor Radiation Oncology and Chief Scientist Radiation Oncology Research Lab
Division Leader in Basic and Translational Cancer Biology (GROW institute for Oncology)
Date：Friday, May 29, 2015, 4-5 p.m.
Place：W3 Seminar Room, West Building, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Vooijs has been actively studying Notch signaling, hypoxia and cancer cell proliferation at the University of Maastricht. We would like to take this opportunity of his visit to Japan to discuss the latest results of his research. We look forward to seeing you there. For details, please click here.
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
February 16, 2015
Regulation of Neuronal Development via Nedd4 Family E3 Ubiquitin Ligase
Hiroshi Kawabe
Group Leader at Max Planck Institute of Experimental Medicine
Date：Monday, February 16, 2015, 1-2:00 p.m.
Place：Seminar Room 4, 4th floor, Faculty of Pharmaceutical Sciences, The University of Tokyo
Dr. Hiroshi Kawabe is a group leader at the Max Planck Institute of Experimental Medicine, where he is actively working on biological phenomena regulated by proteolysis, especially Nedd4 family E3 ubiquitin ligases. We have arranged an opportunity to hear about his latest results on the occasion of his return to Japan. We look forward to seeing you there. For details, please click here.
References:
Neuron 65: 358-372, 2010
Nat. Rev. Neurosci. 12: 251-268, 2011
Proc. Natl. Acad. Sci. USA. 111: 13205-13210, 2014
Contact
Graduate School of Pharmaceutical Sciences, The University of Tokyo Taisuke Tomita
tel 03-5841-4868 (ext. 24868) email: taisuke{at}mol.f.u-tokyo.ac.jp
July 18, 2015
Microglia and exosome-mediated propagation of tau protein in Alzheimer's disease
Professor Tsuneya Ikezu, M.D., Ph.D.
Professor of Pharmacology & Experimental Therapeutics and Neurology, Boston University School of Medicine
Date：Friday, July 18, 2014, 3-4 p.m.
Place：Seminar Room 6, 13F, Education and Research Building, School of Medicine, The University of Tokyo
After graduating from the University of Tokyo School of Medicine, Dr. Tsuneya Ikezu devoted himself to Alzheimer's disease research in the United States and is currently a professor at Boston University School of Medicine, where he leads research on disease mechanisms related to microglia and tau. We are pleased to have this opportunity to meet with him and learn about his latest research results. We look forward to seeing you there.
Contact
Graduate School of Medicine, The University of Tokyo Takeshi Iwatsubo
tel 03-5841-3541 (内23541) email: iwatsubo{at}m.u-tokyo.ac.jp
Protocol
Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
Genta Ito, Taisuke Tomita
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