略歴書（2023（令和5）年9月1日　現在）  English version

富田　泰輔（とみた　たいすけ）　　昭和48年1月22日　生

E-mail: taisuke＠mol.f.u-tokyo.ac.jp
Tel: +81-3-5841-4868
Lab website: https://neuropsc.f.u-tokyo.ac.jp/
ORCID ID: 0000-0002-0075-5943

学歴

職歴および研究歴

受賞歴

所属学会

日本生化学会（2022年より評議員（薬学）、2023年より理事）
日本薬学会会員（2021年より代議員（関東支部2））

日本認知症学会（2006年より評議員（2015年より代議員・基礎研究促進委員会メンバー、2016年より監事、2017年より理事、2018年より基礎研究促進委員会委員長）
日本神経科学会（2023年よりNSR委員会委員、評議員（ドメインC）、幹事）

日本分子生物学会
神経組織培養研究会（2016年より世話人）

日本神経学会
日本病態プロテアーゼ学会（2020年より評議員）

レギュラトリーサイエンス学会（2023年より理事）
Society for Neuroscience
American Society for Biochemistry and Molecular Biology
ISTAART
International Proteolysis Society (Council member 2016-2019)

Editorial Board

Molecular Neurodegeneration (2006-2015)
PLoS ONE (2012-2018)
The Journal of Biological Chemistry (2013-)
Scientific Reports (2016-)
Frontiers in Molecular Neuroscience (2017-)
JoVE (2018-)
Section Editor of Neuroscience Research (2023-、Associate Editor: 2018-2023)

代表原著論文（157報中20報、*: Corresponding author）

1) Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Gruenberg J, Haass C, Iwatsubo T*, Obata K*: The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 94:2025-203, 1997
2) Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T*: C terminus of presenilin is required for overproduction of amyloidogenic Aβ42 through stabilization and endoproteolysis of presenilin. J Neurosci 19:10627-10634, 1999
3) Kamenetz F, Tomita T, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R*: APP processing and synaptic function. Neuron 37:925-937, 2003
4) Takasugi N, Tomita T*, Hayashi I, Tsuruoka M, Niimura M, Thinakaran G, Takahashi Y, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature 422:438-441, 2003
5) Sato C, Morohashi Y, Tomita T*, Iwatsubo T: Structure of the catalytic pore of γ-secretase probed by the accessibility of substituted cysteines. J Neurosci 26:12081-12088, 2006
6) Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T*, Higuchi T: Inhibition of γ-secretase activity by helical α-peptide foldamers. J Am Chem Soc 131:7353-7359, 2009
7) Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T*, Iwatsubo T: Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J 30(23):4815-4824, 2011
8) Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T*, Iwatsubo T: Activity-dependent Cleavage of Neuroligin 1. Neuron 76:410-422, 2012
9) Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T*, Iwatsubo T: Decreased CALM expression reduces Aβ42 to total Aβ through clathrin-mediated endocytosis of γ-secretase. Nat Commun 5:3386, 2014.
10) Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, Fukuyama T, Tomita T*, Iwatsubo T: Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proc Natl Acad Sci USA 111:10544-10549, 2014
11) Cai T, Yonaga M, Tomita T*: Activation of trimming activity of the γ-secretase by topological changes of transmembrane domain 1 of presenilin 1. J Neurosci 37:12272-12280, 2017
12) Kidana K, Tatebe T, Ito K, Saito T, Kikuchi K, Takatori S, Ouchi Y, Saido T, Makino M, Akishita M, Iwatsubo T, Hori Y, Tomita T*: Loss of astrocyte-derived kallikrein 7 exacerbates amyloid pathology in Alzheimer disease model mouse. EMBO Mol Med e8184, 2018
13) Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Dore V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Iwamoto S, Ito K, Tanaka K, Masters CL, Yanagisawa K*: High performance plasma Aβ-amyloid biomarkers for Alzheimer’s disease. Nature 554:249-254, 2018
14) Ni J, Taniguchi A, Kuninobu Y, Ozawa S, Hori Y, Kuninobu Y, Saito T, Saido TC, Tomita T, Sohma Y, Kanai M*: Near-infrared photoactivatable oxygenation catalysts of amyloid protein. Chem 4:807-820, 2018
15) Suzuki T, Hori Y, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T*: Photo-oxygenation inhibits tau amyloid formation. Chem Comm 55: 6165-6168, 2019
16) Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Structures of α-synuclein filaments from multiple system atrophy. Nature 585:464-469, 2020
17) Nagashima N, Ozawa S, Furuta M, Oi M, Hori Y*, Tomita T*, Sohma Y*, Kanai M*: Catalytic photooxygenation reduces brain Aβ in vivo. Sci Adv 7(13): eabc9750, 2021
18) Ozawa S, Hori Y, Shimizu Y, Taniguchi A, Suzuki T, Wang W, Chiu YW, Koike R, Yokoshima S, Fukuyama T, Takatori S, Sohma Y*, Kanai M*, Tomita T*: Photo-oxygenation by a biocompatible catalyst reduces Aβ levels in the brains of Alzheimer disease model mice. Brain 144(6):1884-1897, 2021
19) Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido TC, Ikezu T, Takai T, Sasaki T, Tomita T*: INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience26(4):106375, 2023
20) Matsuzaki M, Yokoyama M, Yoshizawa Y, Kaneko N, Naito H, Kobayashi H, Korenaga A, Sekiya S, Ikemura K, Opoku G, Hirohata S, Iwamoto S, Tanaka K, Tomita T*: ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711. Mol Psychiatry 28(4):1802-1812, 2023

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